نوع فایل:PDFتعداد صفحات:9سال انتشار:1395چکیدهCancer is a collection of biological processes in the human body considered as one of the mostproblematic diseases. Oral cancer is one of the worlds most advanced stages cancer withconvenient access, because its existence is not the patients chance of being alive. The mechanisticand biological pathways study has helped better and faster prognosis and treatment of cancer. Inthis study, OSCC data were analyzed with genetrail 2, the major rout of estrogen signaling pathwayin cancer effect we reached in the OSCC. The analysis identified seven genes associated with theestrogen pathway in keg analyses. Sex hormone estrogen in men and women plays a fundamentalrole, but with changes to its receptor, causes cancer. Considering studies in OSCC estrogenreceptor (ER) alpha is more important contact to miR-125a can be reduced apoptosis. Studies haveshown that only influencing of mir-125a associated with the estrogen receptor in OSCC has beenfound. So After synthesis mir-125a in oral cancer mortality can be recovery and reach to newdrugsواژگان کلیدیoral cancer, estrogen receptor, targets